Adriamycin RDF
Adriamycin
CAS: 23214-92-8
Molecular Formula: C27H29NO11
Adriamycin RDF - Names and Identifiers
Adriamycin RDF - Physico-chemical Properties
| Molecular Formula | C27H29NO11 |
| Molar Mass | 543.53 |
| Density | 1.3783 (rough estimate) |
| Melting Point | 205°C |
| Boling Point | 617.77°C (rough estimate) |
| Flash Point | 443.8°C |
| Water Solubility | Soluble |
| Vapor Presure | 9.64E-28mmHg at 25°C |
| pKa | pKa 8.2 (Uncertain) |
| Storage Condition | Keep in dark place,Sealed in dry,2-8°C |
| Refractive Index | 1.6400 (estimate) |
| Physical and Chemical Properties | The hydrochloride is an orange-red needle-like crystal. Melting Point 204-205 °c. Soluble in water, methanol. The aqueous solution was stable. Insoluble in benzene, ether, chloroform. |
| Use | Clinical for acute and chronic lymphocytic leukemia and solid tumor treatment. This product adverse reactions have myelosuppression myocardial toxicity. |
Adriamycin RDF - Risk and Safety
| Toxicity | An anthracycline cytotoxic antineoplastic that is produced by Streptomyces peucetius. The LD50 in mice is 9.4 mg/kg, i.v. It is a carcinogen that inhibits DNA and RNA synthesis by intercalating in double-stranded DNA with the amino sugar in the minor groove and the 90-OH group of the anthracycline ring hydrogen-bonded to the adjacent guanine. It also alters membrane fluidity and ion transport, and generates free radicals through a cytochrome P450-mediated reductive process. In humans, it causes alopecia, stomatitis, nausea, vomiting, diarrhea, cardiotoxicity (manifested by tachycardia), and potentially fatal congestive heart failure. |
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